منابع مشابه
Hypoxic pulmonary vasoconstriction: ups and downs of reactive oxygen species.
Reduction in alveolar oxygen tension causes reversible hypoxic pulmonary vasoconstriction (HPV), which is thought to serve as an adaptive mechanism for diverting blood flow from poorly ventilated to betterventilated regions of the lung to improve ventilationperfusion matching. Since first described by Von Euler and Liljestrand1 50 years ago, significant advances have been made in determining th...
متن کاملResponse of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling.
Mitochondria are proposed to play an important role in hypoxic cell signaling. One currently accepted signaling paradigm is that the mitochondrial generation of reactive oxygen species (ROS) increases in hypoxia. This is paradoxical, because oxygen is a substrate for ROS generation. Although the response of isolated mitochondrial ROS generation to [O(2)] has been examined previously, such inves...
متن کاملO 22: Reactive Oxygen Species and Epilepsy
Seizure activity has been proposed to result in the generation of reactive oxygen species (ROS), which then contribute to seizure-induced neuronal damage and eventually cell death. Although the mechanisms of seizure-induced ROS generation are unclear, mitochondria and cellular calcium overload have been proposed to have a crucial role. We aim to determine the sources of seizure-induced ROS and ...
متن کاملCALL FOR PAPERS Oxygen Sensing: Life and Death of a Cell Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling
Hoffman DL, Salter JD, Brookes PS. Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling. Am J Physiol Heart Circ Physiol 292: H101–H108, 2007. First published September 8, 2006; doi:10.1152/ajpheart.00699.2006.—Mitochondria are proposed to play an important role in hypoxic cell signaling. One currently accepted sign...
متن کاملHypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival*S⃞
Under hypoxic conditions, cells suppress energy-intensive mRNA translation by modulating the mammalian target of rapamycin (mTOR) and pancreatic eIF2alpha kinase (PERK) pathways. Much is known about hypoxic inhibition of mTOR activity; however, the cellular processes activating PERK remain unclear. Since hypoxia is known to increase intracellular reactive oxygen species (ROS), we hypothesized t...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2007
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1776iti3